Adding a certain compound to certain chemical reactions, such as: 3001-72-7, 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3001-72-7, blongs to pyrimidines compound. category: pyrimidines
General procedure: The reaction mixture of azlactones 1a-p (0.2mmol) and DBN (2b, 0.03mL, 0.22mmol) was stirred at room temperature for the appropriate time according to Scheme 2. After completion of the reaction as monitored by TLC (eluent: petroleum ether/ethyl acetate, 4:1), the mixture was extracted with ethyl acetate (3¡Á5mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by silica gel column chromatography (10-35% ethyl acetate in petroleum ether) afforded the products 3ab-pb. 4.3.1 N-(1-(4-nitrophenyl)-3-oxo-decahydropyrrolo[1,2-a]pyrrolo[2,1-b]pyrimidin-2-yl)benzamide ( Scheme 2 , 3ab) 73.5 mg (0.18 mmol, 88%) as a light orange solid. m.p. 137-138 C (decomposed); IR (KBr): 3344, 2926, 2853, 1692, 1673, 1515, 1461, 1345 cm-1; 1H NMR (400 MHz, DMSO-d6): delta 9.82 (s, 1H), 8.27 (d, J = 8.8 Hz, 2H), 7.87 (d, J = 8.8 Hz, 2H), 7.82 (d, J = 7.2 Hz, 2H), 7.56 (t, J = 7.2 Hz, 1H), 7.46 (t, J = 7.4 Hz, 2H), 4.30 (td, J = 10.4, 2.2 Hz, 1H), 3.56 (dt, J = 12.0, 4.8 Hz, 1H), 3.46 (td, J = 10.2, 2.4 Hz, 1H), 3.24-3.13 (m, 1H), 2.96-2.83 (m, 1H), 2.68-2.57 (m, 1H), 2.45-2.31 (m, 1H), 2.08-1.96 (m, 1H), 1.81-1.77 (m, 2H), 1.73-1.60 (m, 1H), 1.35-1.24 (m, 1H); 13C NMR (100 MHz, CDCl3): delta 167.9, 164.5, 147.1, 142.4, 139.8, 133.2, 132.4, 129.6, 128.7, 127.5, 125.8, 122.8, 83.2, 51.9, 44.2, 38.6, 32.8, 21.2, 19.9; Anal. calcd for C23H22N4O4 (418.19): C 66.05, H 5.26, N 13.39; found C 65.98, H 5.29, N 13.43.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3001-72-7, its application will become more common.
Reference:
Article; Parhizkar, Golnaz; Khosropour, Ahmad Reza; Mohammadpoor-Baltork, Iraj; Parhizkar, Elahehnaz; Rudbari, Hadi Amiri; Tetrahedron; vol. 73; 11; (2017); p. 1397 – 1406;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia