Adding a certain compound to certain chemical reactions, such as: 26032-72-4, 2,4-Dichloro-6-phenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C10H6Cl2N2, blongs to pyrimidines compound. COA of Formula: C10H6Cl2N2
4.5 g of 4-phenyl-2,6-dichloropyrimidine (20 mmol, 2 eq), 3.77 g of ((4-(12H-benzofuro[2,3-a]carbazol-12-yl)phenyl)boronicacid) 10mmol, 1eq) 2M potassium carbonate solution: toluene: ethanol = 1:2:1 (volume ratio, total 80ml), N2 extraction three times to ensure an oxygen-free environment,0.116 g of tetrakistriphenylphosphine palladium (0.1 mmol, 1% eq) was added under the protection of N2.N2 was pumped out three times to ensure an oxygen-free environment, and the temperature was raised to 90 C under the protection of a continuous N2 flow to maintain the reaction.After completion of the reaction, toluene and ethanol were distilled off under reduced pressure.Aqueous phase was extracted with dichloromethane to give organic phase was dried over anhydrous magnesium sulfate, mixed with silica gel sample was added, was subjected to column chromatography to give the product 3.9g (75%);
At the same time, in my other blogs, there are other synthetic methods of this type of compound,26032-72-4, 2,4-Dichloro-6-phenylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Huazhong University of Science and Technology; Wang Lei; Zhang Qing; Zhuang Shaoqing; (40 pag.)CN108285452; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia