Related Products of 34253-03-7 ,Some common heterocyclic compound, 34253-03-7, molecular formula is C6H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of methyl pyrimidine-2-carboxylate (25 g, 181 mmol, 1.0 equiv) in MeOH (500 mL) was added NaBH4 (8.2 g, 217 mmol, 1.2 equiv) at 0C. The reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was quenched with EbO (10 mL), concentrated in vacuo and the residue was purified by flash column chromatography (PE/EtOAc = 1/1) to afford the title compound pyrimidin-2-ylmethanol as a yellow oil (16 g, 80% yield). (1558) LC-MS: m/z 111.0 (M+H)+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,34253-03-7, its application will become more common.
Reference:
Patent; ANNAPURNA BIO, INC.; TANG, Haifeng; HANSON, Michael; BOYCE, Sarah; NIE, Zhe; (461 pag.)WO2020/73011; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia