Electric Literature of 39876-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine, molecular formula is C10H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Finally, 3- [6- (9,9-dimethyl-fluoren-2-yl) dibenzothiophene-4-yl] phenyl boronic acid pinacol ester 0.45g, 4- chlorobenzoate furo [3,2-d ] pyrimidine 0.14g, flask, 0.45g potassium phosphate, dioxane, 4mL, 0.16g t- butanol, a three-necked, flask was replaced air by nitrogen;Then, 1.8mg of palladium acetate, di (1-adamantyl) -n- butyl phosphine was added to 5.6mg pin, and the mixture was allowed to promote the reaction to reflux.Water was added to the obtained mixture, and the solution was extracted with ethyl acetate.Washed with saturated aqueous sodium chloride, the addition of magnesium sulfate, and filtered nature.Removing the solvent of the filtrate was evaporated, toluene: hexane = 1: 5 by purifying the (volume ratio) by flash column chromatography using as a developing solvent to obtain a yellow solid in a yield of 10%.It shows a synthetic scheme of Step 5 in the formula (e-3).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine.
Reference:
Patent; Handotai Enerugi Ken kyushu Corporation; Inoue, Hideko; Ghanamoto, Miki; Seo, Hiromi; Takahashi, Tsuyoshi; Nakagawa, Tomoka; (80 pag.)KR2015/132837; (2015); A;,
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