Related Products of 39876-88-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine, molecular formula is C10H5ClN2O, molecular weight is 204.61, as common compound, the synthetic route is as follows.
A mixture of 4-chlorobenzofuro[3,2-djpyrimidine (1.01 g, 4.94 mmol) and (4-bromo-2-fluorophenyl)methanamine (1.04 g, 5.10 mmol) in acetonitrile (50 mL) in apressure bottle was treated with Hunig?s base (1.6 mL, 9.16 mmol) and the resulting suspension stirred at RT for 10 mm, then heated to 120 C in an oil bath. After 5 hours the mixture went into solution and was then stirred for 16 hours overnight. A pale yellow solid had formed while at 120 C, then the reaction mixture was cooled to RT. Themixture was filtered and washed with CH3CN, and was dried under vacuum to give 1.43 g (78%) ofN-(4-bromo-2-fluorobenzyl)benzofuro[3,2-djpyrimidin-4-amine as a pale yellow solid. LCMS (M+1) = 371.6/373.6.
The chemical industry reduces the impact on the environment during synthesis 39876-88-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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