In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15846-19-2, name is 4-Chloro-6-methoxypyrimidin-5-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 15846-19-2
Prepared as described forN-cyclohexyl-4-iodopyridin-3-amine (Intermediate 17), to a stirred solution of 4-chloro-6-methoxypyrimidin-5-amine (CAS 15846-19-2; 200 mg, 1.25 mmol) and cyclopentanone (CAS 120-92-3; 0.33 mL, 3.76 mmol) in anhydrous DCM (6 mL) under an atmosphere of N2at 0 C was added dropwise T1CI4solution (iM in DCM, 1.4 mL, 1.38 mmol). The reaction was stirred at room temperature for 2 h. Sodium triacetoxyborohydride (797 mg, 3.76 mmol) was added portionwise and the reaction stirred at room temperature for 16 h. The crude product was purified by column chromatography (silica, 0-50% EtOAc / petroleum ether) to afford the title compound. 1H NMR (400 MHz, CHLOROFORM-d) 8 ppm 1.33 – 1.53 (m, 2 H) 1.55 – 1.82 (m, 4 H) 1.83 – 2.00 (m, 2 H) 3.73 (d, J=9 Hz, 1 H) 4.04 (s, 3 H) 4.18 – 4.42 (m, 1 H) 8.08 (s, 1 H) MS ES+: 228
The synthetic route of 15846-19-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DAVENPORT Richard; DUNN Jonathan; FARNABY William; HANNAH Duncan; HARRISON David; WRIGHT Susanne; WO2015/198046; A1; (2015);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia