Electric Literature of 41103-17-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 41103-17-7, name is Ethyl 4-chloropyrimidine-5-carboxylate. A new synthetic method of this compound is introduced below.
2.1 g of the compound obtained in step 2) above and 2.64 g of 3-chloro-4- (pyridin-2-ylmethoxy)benzenamine were dissolved in 20 mL of 2-propanol, and the mixture was stirred for 3 hours. After the reaction was completed, the resulting solution was cooled to room temperature and distilled under a reduced pressure. The resulting residue was subjected to column chromatography (ethyl acetate : dichloromethane: methanol = 7 : 7 : 1) to obtain the title compound (2.0 g).1H-NMR (300MHz, CDC13) delta 10.32 (s, 1H), 9.01 (s, 1H), 8.79 (s, 1H), 8.60 (d, 1H), 7.82 (d, 1H), 7.75 (t, 1H), 7.73 {d, 1H), 7.43 (dd, 1H), 7.01 (dd, 1H), 5.29 (s, 2H), 4.34 (m, 2H), 1.26 (t, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41103-17-7, its application will become more common.
Reference:
Patent; HANMI HOLDINGS CO., LTD.; CHA, Mi Young; KIM, Mi Ra; KANG, Seok Jong; KIM, Se Young; JUNG, Young Hee; LEE, Kwang Ok; SONG, Ji Yeon; KIM, Young Hoon; KIM, Eun Young; KIM, Maeng Sup; WO2011/99764; (2011); A2;,
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