45588-79-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 45588-79-2, name is 4-(Aminomethyl)pyrimidine. A new synthetic method of this compound is introduced below.
To a stirred solution of 4-(cis-8-(dimethylamino)-3-oxo-8-phenyl-2-azaspiro[4. 5]decan-2- yI)-2,2-dimethylbutanoic acid hydrochloride (300mg, 0.71 mmol) in THF(1 0mL), diisopropylethylamine (490mg, 3.8Ommol) and HATU (541mg, 1 .43mmol) were added at RT. The reaction mixture was stirred at RT for 45mm and then pyrimidin-4-yl- methanamine (114mg, 1 .O45mmol) was added at 0C. The reaction mixture was warmedto RT and stirred for 16h. The reaction mixture was quenched with saturated NaHCO3 Solution, extracted with 10%methanol in DCM (3X25mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude compound. Purification by column chromatography over silica gel (100-200 mesh) by using 1 0%methanol in DCM with traces of ammonia as eluent to give 160mg ofcompound which was further purified by preparative TLC by using 5% methanol in DCM as mobile phase to give 110 mg (33%) of cis- 4-(8-Dimethylamino-3-oxo-8-phenyl-2- azaspiro[4.5]decan-2-yl)-2,2-dimethyl-N-(pyrimidin-4-yl-methyl)-butyramide as solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 45588-79-2, 4-(Aminomethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GRUeNENTHAL GMBH; WEGERT, Anita; KUeHNERT, Sven; KOENIGS, Rene, Michael; NOLTE, Bert; LINZ, Klaus; HARLFINGER, Stephanie; KOeGEL, Babette-Yvonne; RATCLIFFE, Paul; THEIL, Fritz; GROeGER, Olga; BRAUN, Birgit; (223 pag.)WO2016/8582; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia