In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. COA of Formula: C5H5ClN2S
Example 14: Synthesis of 6-(2-Chloro-phenoxy)-3-thiophen-2-yl-lH-pyrazolo[3,4-d]- pyrimidine; Step 1. Preparation of4-Chloro-2-methanesulfonyl-pyrimidine; 4-Chloro-2-methanesulfanyl-pyrimidine (15.0 g, 98.38 mmol) was dissolved in 220 mL MeOH and cooled to 00C. OXONE (potassium peroxymonosulfate, 97 g) dissolved in 350 mL was added, and the reaction mixture was stirred at 00C for two hours. Approximately 2/5 of the volume of the reaction mixture was then removed under reduced pressure, and 10% aqueous sodium bicarbonate was carefully added. The mixture was partitioned with 300 mL EtOAc and the organic phase was separated. The aqueous phase was washed twice with 200 mL of EtOAc, and the combined organic layers were washed with brine, dried over MgSO4, filtered, and evaporated under reduced pressure to yield 15.23 g of crude 4- chloro-2-methanesulfonyl-pyrimidine. Mass Spec. M+H = 193.
The synthetic route of 49844-90-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/23105; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia