Synthetic Route of 87362-32-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 87362-32-1, name is 5-Methoxypyrimidine-2-carbonitrile. A new synthetic method of this compound is introduced below.
A mixture of 5-methoxypyrimidine-2-carbonitrile (100 mg, 0.74 mmol) and B C O (194 mg, 0.89 mmol) and MeOH (5 mL) was added to Raney-Ni (30 mg, 10%), the reaction mixture was stirred at room temperature for 2 hours under a H atmosphere (45 psi). The reaction mixture was filtered to remove the catalyst and the filter cake was washed with MeOH (10 mL c 3), and the filtrate was concentrated under vacuum. The crude product was purified by flash chromatography on silica gel (0~10% ethyl acetate in petroleum ether) to give ferf-butyl ((5-methoxypyrimidin-2- yl)methyl)carbamate.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,87362-32-1, 5-Methoxypyrimidine-2-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (275 pag.)WO2019/115566; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia