Reference of 1088994-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1088994-22-2, name is 5-Methyl-2-(pyrimidin-2-yl)benzoicacid, molecular formula is C12H10N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 62:Compound 13: (S)-(5-(((5-chloropyridin-2-yl)amino)methyl)-6-azaspiror2.51octan-6- yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone (Isomer A) HPLC retention time: 9 min (150 mg)Alternatively Compound 13 was obtained by the following procedure: 5-methyl-2- (pyrimidin-2-yl)benzoic acid (428mg, 2mmol; prepared according to WO 2008147518), intermediate 34 (500mg, 2mmol) and DIPEA (0.65ml) were dissolved in DCM (5ml) at 0 C, then T3P (50% in DCM, 1.5g) was added. The mixture is stirred at reflux for 8 hours then at RT overnight. The reaction was washed with NaOH 1 M and water, dried (Na2SO4) and evaporated. The crude was purified by silica gel column chromatography (DCM to DCIWMeOH = 95/05). 180mg of the desired compound were isolated.MS (ESI); m/z 446 [MH]+1HNMR [the product is present as a mixture of conformers. The assignment refers to the major component] (CDCI3) d ppm 8.80-8.77 (m, 1 H) 8.64-8.6 (d, 1 H) 8.36- 8.31 (d, 1 H) 8.08-8.04 (m, 1 H) 7.43-7.17 (m, 3H) 7.08-7.03 (t,1 H) 6.36-6.31 (d, 1 H) 5.79 (bs, 1 H) 5.19-5.1 1 (m, 1 H) 4.00-3.89 (m, 1 H) 3.71 -3.62 (m, 1 H) 3.50-3.39 (m, 1 H) 3.37-3.21 (m, 1 H) 2.45 (s, 3H) 2.31 -2.24 (dd, 1 H) 1.99-1.88 (dt, 1 H) 1.25- 1.19 (d, 1 H) 0.75-0.68 (d, 1 H) 0.60-0.13 (m, 4H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1088994-22-2, 5-Methyl-2-(pyrimidin-2-yl)benzoicacid.
Reference:
Patent; ROTTAPHARM S.P.A.; STASI, Luigi, Piero; ROVATI, Lucio; WO2011/6960; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia