Adding a certain compound to certain chemical reactions, such as: 5305-59-9, 6-Chloropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5305-59-9, blongs to pyrimidines compound. name: 6-Chloropyrimidin-4-amine
The 0.96 g (10 mmol) of 1H-imidazole-4-carbaldehyde was dissolved in 20 ml of DMF, and 1.30 g (10 mmol) of 4-amino-6-chloropyrimidine, 2.07 g (15 mm1) of potassium carbonate was added successively 100 C, stirring reaction 12h. The appropriate amount of water was added and extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate and then filtered to remove the solvent under reduced pressure. The residue was purified by silica gel column The eluent was methanol: dichloromethane = 1: 30 to give 0.87 g of a white solid (compound represented by the formula Pialpha) in a yield of 46%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5305-59-9, its application will become more common.
Reference:
Patent; East China University of Science and Technology; Mao Fei; Xu Yixiang; Li Xiaokang; Liu Wenwen; Li Jian; (26 pag.)CN106946854; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia