56-09-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one, molecular formula is C4H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2-amino-pyrimidine-4,6-diol 28.00g (0.22mol), thionyl chloride 80ml (1.1mol) into 250ml 4-neck flask, heated to reflux for 4h.After completion of the reaction, the heat is turned off, cooled to room temperature, the reaction was quenched by slowly poured into ice water.In this case large amount of solid precipitated, filtered off with suction, the filter cake was rinsed with potable water to pH 7.The wet cake at 60 deg.] C blast drying to constant weight, to give a pale yellow product 33.45g, this step a yield of 92.7%, HPLC purity was 99.1%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Weihai Disu Pharmaceutical Co., Ltd.; Disha Pharmaceutical Group Co., Ltd.; Liu Chao; Ge Zhixin; Li Tingyi; Miao Huaming; Cai Yahui; (13 pag.)CN109456329; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia