As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one, molecular formula is C4H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 56-09-7
To an ice-cold stirred solution of POCl3 (9.72g, 63.38 mmol) was added dry DMF dropwise over a period of 5 minutes. The ice-bath was removed, andIntermediate EE (1.0g, 7.87 mmol) was added in small portions under stirring and N2 atmosphere. After the exothermic reaction ceased, the reaction mixture was brought up to 100C and stirred for 1.5 hours. The solution was cooled to room temperature, reduced to half the volume under reduced pressure, poured into ice- ater (15 mL), and warmed to 50C for 2 hours. A pale yellow precipitate then separated out, and the precipitate was filtered, washed with water (~10 mL) and acetone (-10 mL), and then dried. The Intermediate FF (580 mg, 38.4%) was obtained as pale yellow solid. 1H NMR (300 MHz, DMSO-i?) delta 10.05 (s, CHO), 8.49 (s, 2H, D20 exchangeable).
The chemical industry reduces the impact on the environment during synthesis 56-09-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian; WO2011/35009; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia