Simple exploration of 5604-46-6

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, molecular formula is C5H3Cl2N3O, molecular weight is 192.0028, as common compound, the synthetic route is as follows.HPLC of Formula: C5H3Cl2N3O

A solution of lambda/-methylpiperazine (0.624ml), 2-amino-4,6-dichloro-5- formylpyrimidine (1.0Og) and DIPEA (0.936ml) in NMP (120ml) is stirred at room temperature for 18 hours. After addition of MTBE (400ml) the mixture is washed with a saturated solution of NaHCtheta3 (2 x 120ml) and brine (1 x 50ml), dried (MgStheta4) and concentrated to give the title compound as a colourless oil (509mg, 38%). LCMS 255/257 [M+H]+ (pH5.8), RT 1.67 mins. 1H NMR 300 MHz (d6-DMSO) (delta ppm): 10.07 (1H, s), 5.32 (2H1 bs), 3.66 – 3.58 (4H, m), 2.57 – 2.46 (4H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; UCB PHARMA, S.A.; WO2008/74445; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia