Synthetic Route of 705263-10-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 705263-10-1, name is 6-Bromopyrazolo[1,5-a]pyrimidine, molecular formula is C6H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
6-Bromo-pyrazolo [1,5-a] pyrimidine (2.0 g, 10.0 mmol) dissolved in 20 mL of toluene, [1,1′-bis (diphenylphosphino) ferrocene Fe] dichloropalladium (0.7 g, 1 mmol), potassium acetate (4.0 g, 40.0 mmol) and the associated acid pinacol ester (5.1 g, 20.0 mmol) were added in the flask. It was heated to reflux under argon for 5 h, and TLC monitoring of the reaction process until the starting material disappeared stop heating. The reaction solution was cooled to room temperature and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether / ethyl acetate). White solid, yield: 65%. 1H NMR (CDCl3, 400 MHz, delta ppm):8.71 (d, J = 1.6 Hz, 1H), 8.17 (d, J = 2.2 Hz, 1H), 1.38 (s, 12H). ESI-MS(m/z): 246.1 [M+H]+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 705263-10-1, 6-Bromopyrazolo[1,5-a]pyrimidine.
Reference:
Article; Hu, Liming; Cao, Tingting; Lv, Yongjuan; Ding, Yiming; Yang, Leifu; Zhang, Qiang; Guo, Mingzhou; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5830 – 5835;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia