Electric Literature of 62802-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62802-42-0, name is 2-Chloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below.
The title compound 3Ki) was made by dissolving tert-butyl pipera?ine-1-carboxylate (0.53 g, 2.9 mmol) and 2-chloro-5-fluoropyrimidine (0.42 g, 3.2 mmol) in propan-2-ol (3 mL) and DIEA (1.1 mL, 6.4 mmol). The mixture was sealed under nitrogen in a microwave vessel, heated to 120 0C for 0.5 h with microwave energy and then cooled to 25 0C. The solution was diluted with ethyl acetate (50 mL) and washed with 0.1 N HCI and saturated aqueous sodium bicarbonate (2 X 50 mL). The organic layer was dried over Na2SO4, then filtered through silica gel plug (5 mL) and concentrated to afford title product as a white solid (0.85g, 80%). HPLC Rt: 3.485 min. (98.5 %); 1H NMR (400 MHz, CDCI3), delta ppm: 1.49 (s, 9 H), 3.32 – 3.61 (m, 4 H), 3.64 – 3.95 (m, 4 H), 8.21 (s, 2 H); LRMS (ESI): mlz (M +H – t-Butyl): 227.1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,62802-42-0, 2-Chloro-5-fluoropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER INC.; WO2006/106423; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia