As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 252723-16-3, name is 7-Benzenesulfonyl-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C13H10ClN3O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C13H10ClN3O2S
The compound 1 (10.83 mmol), compound 2 (10.83 mmol), PdCl2(Dppf) (527 mg, 0 . 72 mmol) and KOAc (235 mg, 2.4 mmol) in toluene (30 ml) in the mixture is heated to 110 C maintain 6 hours. The reaction liquid evaporation and adding water (100 ml), and ethyl acetate (2 × 40 ml) extraction. Separating the organic phase, using anhydrous Na2SO4 drying, filtering and evaporation. Through column chromatography ethyl acetate/petroleum ether=1:4 – 1:1 to carry out the purification, to obtain 2 g solid, in THF: H 20 (24 ml: 6 ml) in the mixed solvent are added in the solution of NaIO4(18.6 Mmol), and stirring at room temperature 30 minutes. By adding 2 N HCl aqueous solution. Its stirring at room temperature 3 hours. The mixture of ethyl acetate dilution, salt water for washing, then separating and anhydrous Na2SO4Drying, filtering and concentrating. Through the use of MeOH/DCM=1:10 of column chromatography purification to obtain compound 4.
With the rapid development of chemical substances, we look forward to future research findings about 252723-16-3.
Reference:
Patent; Chengdu Shibeikang Bio-pharmaceutical Technology Co., Ltd.; Cen Guodong; Yang Maoting; Tan Shaojun; (8 pag.)CN108191874; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia