Application of 87026-45-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.87026-45-7, name is 4-Chloro-5-methoxy-2-(methylthio)pyrimidine, molecular formula is C6H7ClN2OS, molecular weight is 190.65, as common compound, the synthetic route is as follows.
Ethyl 4-(2-{(3,5-bis-trifluoromethyl-benzyl)-[2-(4,4?5,5-tetramethyl- [1,3 , 2] dioxaborolan-2-yl) – 5-trifluoromethyl-benzyl] -amino}-pyrimidin- 5- yloxy)-butyrate (300mg) is dissolved in 1,4-dioxane (5ml) and thereto are added 4-chloro-5-methoxy-2-methylsulfanil-pyrimidine (117mg), [1, 1′- bis(diphenylphosphino)ferrocene]dichloropalladium dichloromethane complex (33mg) and cesium carbonate (199mg), and the mixture is stirred under nitrogen atmosphere at 80C overnight. The reaction solution is cooled to room temperature, and thereto are added chloroform and water, and the insoluble materials are removed by filtration through Celite. The filtrate is separated, and the organic layer is dried and concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography (hexane : ethyl acetate = 9: 1?7:3) to give ethyl 4-(2-{(3,5- bis-trifluoromethyl-benzyl) – [2- (5-methoxy-2 -methylsulfanil-pyrimidin-4-yl) – 5-trifluoromethyl-benzyl]-amino}-pyrimidin-5~yloxy)-butyrate (165mg). MS (m/z): 764 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 87026-45-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2007/88996; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia