Related Products of 873-83-6 ,Some common heterocyclic compound, 873-83-6, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of 6-aminouracil 1 (2 mmol), aromatic aldehyde 2 (2 mmol), urea (3, 2.5 mmol) and CuI NPs (2.9 mg,15 molpercent) in water (4 mL) was stirred at room temperature for the appropriate time. The progress of the reaction was monitored by TLC. After completion of the reaction,the resulting mixture was filtered. The solid residue was diluted with DMF (10 mL) and centrifuged at 2000?3000 rpm for 5 min to remove the CuI catalyst which was washed with DMF and dried at 100 °C for several hours in a vacuum for reuse. The organic solution was then poured into ice-cold water (10 mL) to give a solid precipitate, which was filtered off and recrystallized from DMF and H2O to afford the pure product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Abdolmohammadi, Shahrzad; Afsharpour, Maryam; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 70; 3; (2015); p. 171 – 176;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia