Adding a certain compound to certain chemical reactions, such as: 89792-11-0, 2-Methyl-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89792-11-0, blongs to pyrimidines compound. Recommanded Product: 89792-11-0
2-Methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 23-a (10.54 g, 70.6 mmol) was dissolved in Toluene (20 mL) under inert atmosphere. DIPEA (24 mL, 141 mmol, 2 eq.) and POC13 (19.5 mL, 212 mmol, 3 eq.) were added dropwise at 70C and the mixture was then heated to 106C. After 16 hours, the solution was concentrated in vacuo, extracted with ethyl acetate and washed with saturated NaHCO3 solution. Thecombined organic layers were dried over Na2504, and concentrated in vacuo to yield a grey oil which was suspended in water/heptanes to afford a white solid intermediate 23(5.9 g, 50%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89792-11-0, its application will become more common.
Reference:
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; COOYMANS, Ludwig, Paul; (105 pag.)WO2016/91774; (2016); A1;,
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