Related Products of 98141-42-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.98141-42-5, name is 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H4Cl2N4, molecular weight is 203.03, as common compound, the synthetic route is as follows.
A mixture of 3-methoxyphenol (70 muL) and NaH (37 mg) in dry THF (3 mL) under N2 was stirred for 30 min. 4,6-Dichloro-l-methyl-lH-pyrazolo[3,4-d]pyrimidine 5 was added. After 18 hr, the reaction mixture was cooled, diluted with water, extracted with EtOAc, dried (Na2SO4), filtered and concentrated in vacuo then purified by flash chromatography to give a 2:1 mixture of 6-chloro-4-(3-methoxy-phenoxy)-l-methyl-lH-pyrazolo[3,4-d]pyrimidine and 3-methoxyphenol.
The chemical industry reduces the impact on the environment during synthesis 98141-42-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; WO2009/97446; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia