Application of 18740-39-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 18740-39-1 as follows.
4-hydroxy-3,5-dimethylbenzonitrile (0.15 g, 1 mmol) and potassium carbonate (0.17 g, 1.2 mmol) were weighed in 5 mLN, N-dimethylformamide (DMF), stirred at room temperature for 15 minutes, and then 2,4-dichlorothieno [2,3-d] pyrimidine(0.21 g, 1 mmol) was added at room temperature for 2 h (TLC detection reaction was complete). At this point there is a lot of white solid generated, slowly To this was added 25 mL of ice water, filtered and dried in a vacuum oven to give the white solid as compound 4 – ((2-chlorothiophene[2,3-d] pyrimidin-4-yl) oxy) -3,5-dimethylbenzonitrile in a yield of 91.7percent
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18740-39-1, its application will become more common.
Reference:
Patent; Shandong University; Liu Xinyong; Kang Dongwei; Zhan Peng; Wu Gaoshan; Huo Zhipeng; (22 pag.)CN106866699; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia