Related Products of 53135-24-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 53135-24-3, name is Ethyl 2-methyl-6-oxo-1,6-dihydropyrimidine-5-carboxylate. A new synthetic method of this compound is introduced below.
ethyl 4-chloro-2-methylpyrimidine-5-carboxylate Phosphorus oxychloride (50 mL, 23.33 mmol) was added to ethyl 2-methyl-6-oxo-1,6-dihydropyrimidine-5-carboxylate (Intermediate 174, 4.25 g, 23.33 mmol). The insoluble mixture was refluxed for 30 minutes. The product was soluble in POCl3 where as the starting material was not. The excess POCl3 was removed under vacuum. The mixture was evaporated to dryness and redissolved in EtOAc (100 mL), and washed sequentially with water (75 mL) and saturated brine (75 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 10 to 30% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford ethyl 4-chloro-2-methylpyrimidine-5-carboxylate (2.70 g, 57.7%) as a colourless oil. 1H NMR (400.132 MHz, CDCl3) delta 1.42 (3H, t), 2.78 (3H, s), 4.44 (2H, q), 9.05 (1H, s) m/z (ESI+) (M+H)+=201; HPLC tR=2.17 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,53135-24-3, its application will become more common.
Reference:
Patent; AstraZeneca AB; US2009/264401; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia