Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 302964-08-5, name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
To a 1L glass vessel equipped with a stirrer and a thermometer probe were added the Formula ic (120 g, obtained by the Example-8b, Step-1), Water (1200 mL, 10.0 vol), Citric acid (73.50 g, 0.507 mol) at 25¡À5 C. The mass was cooled to 10¡À5 C under stirring. Aqueous Ammonia was added very slowly into the reaction mass at a constant rate under stirring. The reaction mass was warmed to 25¡À5 C, the solid material was filtered, washed with water (1000 mL, 10.0 vol) and dried at 55¡À5 C under vacuum to obtain to obtain Amorphous Dasatinib as a solid (94.5 g, 76.35% w.r.t. Formula II, 99.8% AUC, N-Oxide impurity:
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Reference:
Patent; BIOCON LIMITED; BHAT, Ramakrishna, Parameshwar; RAGHUNADHACHETTY, Jithendrababu; KALIAPPAN, Mariappan; PALLE, Venkata, Raghavendracharyulu; REGALLA, VijayBhaskar, Reddy; (123 pag.)WO2019/8555; (2019); A1;,
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