Inhibitors of bovine herpes mammillitis virus infections in cultured cells and in vaginally infected guinea pigs was written by Smee, D. F.; Leonhardt, J. A.; Sugiyama, S. T.; Holy, A.. And the article was included in Antiviral Chemistry & Chemotherapy on July 31,1994.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:
Bovine herpes mammillitis virus or bovine herpesvirus type 2 (BHV-2) causes ulcerative lesions on the teats and udders of infected cows. The authors investigated several nucleoside and nucleotide analogs as potential BHV-2 inhibitors. These included acyclovir, ganciclovir, 5-iodo-2′-deoxyuridine (IUdR), 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl) derivatives of 5-iodocytosine (FIAC), 5-iodouracil (FIAU), and 5-methyluracil (FMAU), and various 3-hydroxyphosphonylmethoxypropyl (HPMP) and 2-phosphonylmethoxyethyl (PME) derivatives of adenine (A), guanine (G), 2,6-diaminopurine (DAP), and/or cytosine (C). Of these, FIAU and FMAU were the most potent in cell culture, inhibiting 50% of BHV-2 plaques at <0.05 μM. HPMPA and HPMPG were active at 0.3 μM; FIAC, IUdR, and HPMPC at 1.3-2.3 μM; PMEDAP and ganciclovir at 20-25 μM; acyclovir and PMEA at >100 μM. The two most potent agents, FIAU and FMAU, inhibited uninfected embryonic bovine tracheal cell growth by 50% at >100 μM and 53 μM, resp., resulting in selectivity indexes (ratio of the 50% inhibitory concentration for cell growth to the 50% inhibitory concentration for plaque formation) of >2200 and 1100. Greater degrees of antiviral activity and selectivity were obtained in infected guinea pig embryo cells treated with FIAU, FMAU, and HPMPC. Infected cell extracts containing BHV-2-induced thymidine kinase activity phosphorylated FIAU, FMAU, and IUdR at nearly the same rate as thymidine, whereas FIAC, acyclovir, and ganciclovir were phosphorylated at ≤5% the rate of thymidine. Phosphorylation by this enzyme is required to generate the antivirally active nucleoside triphosphate in infected cells. In guinea pigs infected intravaginally with BHV-2, FMAU treatments of 1, 3.2, and 10 mg kg-1 per day for 5 days starting 1 day after virus challenge reduced vaginal lesion scores and virus titers in a dose-dependent manner. FIAU (10 μM) was as effective as 1 μM FMAU by the same regimen. A single treatment with 10 μM HPMPC was as active as daily treatments with 3.2 mg FMAU kg-1. These results indicate the potential of using antiviral agents to treat bovine herpes mammillitis virus infections in cattle, and the application of guinea pigs to study BHV-2 disease. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C10H13FN2O5
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3