The inhibition of ultraviolet radiation-induced DNA repair in human diploid fibroblasts by arabinofuranosyl nucleosides was written by Snyder, Ronald D.; Van Houten, Bennett; Regan, James D.. And the article was included in Chemico-Biological Interactions on June 30,1984.Related Products of 56632-83-8 The following contents are mentioned in the article:
The antiviral compounds 9-β-D-arabinofuranosyladenine (ara-A), 9-β-D-arabinofuranosyl-2-fluoroadenine (FAA), 9-β-D-arabinofuranosylhypoxanthine (ara-Hx), 9-β-D-arabinofuranosylguanine (ara-G), 1-β-D-arabinofuranosylthymine (ara-T), 1-β-D-arabinofuranosyl-2′-fluorocytosine (FAC), 1-β-D-arabinofuranosyl-2′-fluoro-5-iodocytosine (FIAC), and 1-β-D-arabinofuranosyl-2′-fluoro-5-methyluracil (FMAU) were compared to 1-β-D-arabinofuranosyl cytosine (ara-C) in their ability to inhibit UV light-induced DNA repair in log phase and confluent human diploid fibroblasts. Inhibition of the polymerization or ligation steps of DNA excision repair manifests itself in the form of DNA single-strand breaks which may be quantitated through velocity sedimentation anal. in alk. sucrose gradients. In UV-irradiated quiescent, confluent human fibroblast cultures, treatment with any of the aranucleosides leads to accumulation of single-strand breaks but the ED for this inhibition varies greatly. The order of their effectiveness in confluent cultures was ara-C and its derivatives >ara-A, FAA, ara-G, Ara-HX > ara-T. In rapidly cycling cells, on the other hand, sensitivity to repair inhibition was exhibited only in response to ara-C and FAC. If 2 mM hydroxyurea (HU) was administered with ara-A, FAA, or FMAU, however, DNA strand breaks were seen. HU also increased the efficiencies of ara-C and FAC. No strand breaks were observed in UV-irradiated log-phase cells treated with FIAC, ara-Hx, ara-G, or ara-T even in the presence of HU. The efficiencies of inhibition of unscheduled DNA synthesis (UDS) and semiconservative DNA synthesis by the aranucleosides is consistent with their relative efficiencies at producing strand breaks. The ability of the aranucleosides to inhibit DNA is discussed with respect to their hypothesized effects on DNA metabolic processes in eukaryotic cells. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Related Products of 56632-83-8).
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