Solberg, Jan; Undheim, Kjell published the artcile< Regiochemistry in palladium-catalyzed organotin reactions with halopyrimidines>, Recommanded Product: 4,5-Dichloro-2-(methylthio)pyrimidine, the main research area is halopyrimidine coupling organotin palladium catalyzed; regiochem halopyrimidine coupling organotin.
Chlorines in activated pyrimidine position are replaced by carbon substituents in Pd-catalyzed reactions with organotin compounds The 4(6)-position is more reactive than the 2-position allowing for regioselective coupling in 2,4(6)-dihalopyrimidines. A bromine substituent is required for coupling in the benzenoid 5-position. In 5-bromo-2,4-dichloropyrimidine the 4-chlorine is replaced before the 5-bromine and the latter before the 2-chlorine substituent, all in a regioselective manner. The methodol. can be used to introduce functionalized carbon substituents into any pyrimidine position.
Acta Chemica Scandinavica published new progress about Coupling reaction. 99469-85-9 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2S, Recommanded Product: 4,5-Dichloro-2-(methylthio)pyrimidine.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia