On July 31, 2013, Solomonov, Alexey V.; Rumyantsev, Evgeniy V.; Ivanov, Sergey P.; Kochergin, Boris A.; Antina, Elena V. published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Spectroscopic studies of the supramolecular interactions between uracil and 5-hydroxy-6-methyluracil with bovine serum albumin and its bilirubin complex. And the article contained the following:
Using fluorescence and UV-visible absorption spectroscopy, the interaction of bovine serum albumin (BSA) and its bilirubin complex with uracil and 5-hydroxy-6-methyluracil in phosphate buffer at pH 7.4 was investigated. The parameters of forming intermol. complexes (binding constants, quenching rate constants, the radius of the quenching sphere, etc.) were determined The interaction between BSA and the uracils was carried out by static quenching of protein fluorescence and had predominantly hydrophobic character. Using synchronous fluorescence spectroscopy, the influence of uracil and 5-hydroxy-6-methyluracil on the conformational changes of the protein mol. was studied. The uracils effectively bound to the bilirubin-BSA complex compared to the free protein, which was caused by the interaction with the tetrapyrrolic pigment in the macromol. complex. Mol. docking calculations were also performed. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to serum albumin interaction uracil hydroxymethyluracil spectroscopy protein conformational change, General Biochemistry: Proteins and Their Constituents and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia