Reference of 10397-13-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10397-13-4, name is 4-(4,6-Dichloropyrimidin-2-yl)morpholine. This compound has unique chemical properties. The synthetic route is as follows.
A solution of (S)-3-methylmorpholine (194 mg, 1.32 mmol, 1.5 eq.), i26 (300 mg, 1 .28 mmol, 1 .0 eq.) and A/,/V-diisopropylethylamine (3.0 eq.) in DMF (17 volumes) is heated for 16 hours (130 C). Then, the solvent is removed under reduced pressure. The residue is dissolved in dichloromethane (100 volumes) and washed with saturated aqueous sodium bisulfate (3 x 100 volumes). The organic layer is dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude mixture is purified by flash chromatography (Si02, cyclohexane/ethyl acetate 5:1 ) to afford the title compound i30 as a colorless solid (257 mg, 67%). 1H NMR (400 MHz, CDCI3): delta 5.84 (s, 1 H), 4.18 (m, 1 H), 3.94 (m, 2 H), 3.71 (m, 10 H), 3.53, (dt, 2JH,H = 12.0 Hz, 3JH,H = 3.1 Hz, 1 H), 3.20 (dt, 2JH,H = 12.8 Hz, 3JH,H = 3.8 Hz, 1 H), 1 .27 (d, 3JH,H = 6.8 Hz, 3 H); MS (MALDI): m/z = 298.4 ([M]+). -(4-chloro-6-morpholino-1 ,3,5-triazin-2-yl)morpholin-3-one (31 )
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10397-13-4, 4-(4,6-Dichloropyrimidin-2-yl)morpholine.
Reference:
Patent; PIQUR THERAPEUTICS AG; UNIVERSITAeT BASEL; CMILJANOVIC, Vladimir; HEBEISEN, Paul; BEAUFILS, Florent; BOHNACKER, Thomas; RAGEOT, Denise; SELE, Alexander; WYMANN, Matthias; LANGLOIS, Jean-Baptiste; (217 pag.)WO2016/75130; (2016); A1;,
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