Related Products of 1333240-17-7 ,Some common heterocyclic compound, 1333240-17-7, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
b. Preparation of Compound 2-(4-Fluorophenyl)-4,5-dimethoxypyrimidine 2-Chloro-4,5-dimethoxypyrimidine (500 mg, 2.86 mmol), (4-fluorophenyl)boronic acid (601 mg, 4.30 mmol), Pd(PPh3)4 (330 mg, 0.29 mmol) and Na2CO3(910 mg, 8.59 mmol) were dissolved in a mixture of dioxane (12 mL) and water (4 niL). The air was evacuated and replaced with N2. Then, the reaction mixture was refluxed for 5 hours. After the reaction was completed, it was cooled to room temperature and it was diluted with EtOAc and washed with sat. NH4CI followed by brine. The organic layer was dried over Na2S04 and concentrated under reduced pressure and the resulting residue was flash chromatographed on silica gel eluting with 0 to 10% EtOAc/Hexane. This afforded 2-(4-fluorophenyl)-4,5-dimethoxypyrimidine as a white solid (123 mg, 77%); m.p.l 14-116 C; LH NMR (400 MHz, CDC13) delta 8.37 (dd, J= 9 Hz, J= 6 Hz, 2H), 8.12 (s, 1H), 7.16 – 7. 12 (m, 2H), 4.17 (s, 3H), 3.98 (s, 3H); 13C NMR (100 MHz, CDCI3) delta 163.1 (JQF= 248 Hz), 159.7, 155.3, 141.0, 137.2, 133.6 (JCIF= 3 Hz), 129.6 (J F= 8 Hz), 115.3 (JC,F= 22 Hz), 56.4, 54.0; 19F NMR (376 MHz, CDC13) delta -11 1.9.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1333240-17-7, 2-Chloro-4,5-dimethoxypyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LAVOIE, Edmond J.; BAUMAN, Joseph David; PARHI, Ajit; SAGONG, Hye Yeon; PATEL, Disha; ARNOLD, Eddy; DAS, Kalyan; VIJAYAN, Suyambu Kesava; WO2014/43252; (2014); A2;,
Pyrimidine | C4H4N2 – PubChem,
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