Some scientific research about 137281-39-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 137281-39-1, 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid, other downstream synthetic routes, hurry up and to see.

137281-39-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 137281-39-1, name is 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid. A new synthetic method of this compound is introduced below.

Example -1: Preparation of Pemetrexed Dimethyl ester of Formula V (R=methyl)4-(2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid (lOg, 0.034 moles) and N,N-dimethylformamide (50 mL) were stirred for 10-15 minutes under nitrogen atmosphere at room temperature and the reaction mass was cooled to 0 – 5C. 1 -Hydroxybenzotriazole (4.53g) and l-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (6.43) was added at 0 -5C and the reaction mass was maintained for 1-2 hours at 0 – 5C. Then L- glutamic acid dimethyl ester Hydrochloride (8.50g, 0.040 moles) and Diisopropyl ethylamine (4.34g) was then added to reaction mass at 0-5C and the temperature was raised to room temperature. The reaction mass was stirred at room temperature for 2-3 hours and DM Water (500ml) was added. The reaction mass was stirred at room temperature for 10-15 hours. The product was thus filtered under vacuum was crystallized with methanol: acetone mixture and Methanol and Dichloromethane mixture. The product was dried under vacuum oven at 50- 55C for 10-15 hours. Yield (w/w) : 12.5gYield (%) : 80.4%Purity : 98.0%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 137281-39-1, 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FRESENIUS KABI ONCOLOGY LTD.; SINGH, Govind; GIRIGANI, Sathyanarayana; KUMAR, Sruzen, Suneel; LAHIRI, Saswata; BUBEY, Sushil, Kumar; WO2012/56285; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia