Synthetic Route of 147118-40-9 ,Some common heterocyclic compound, 147118-40-9, molecular formula is C23H30FN3O6S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Previous to give 62 g (0.125 mol) of crystalline product was added 860 ml of ethanol, 140 ml 1N-NaOH was stirred at 25 degrees for 1 hour. At 35-40 ° ethanol was removed by vacuum distillation, by 1 l methyl t-butyl ether and extracted twice. With an appropriate amount of the aqueous layer was filtered through Celite and activated carbon, with a small amount of water dissolved calcium acetate was added to the filtrate, stirred for 2 hours at 25 °, filtered washed with water, and dried to give 52.9 g (84.5percent theoretical yield) rosuvastatin statin calcium.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,147118-40-9, its application will become more common.
Reference:
Patent; Anhui Menovo Pharmaceuticals Co., Ltd; Fan, qijiao; Wang, bangfeng; Shi, jianxiang; (9 pag.)CN105461636; (2016); A;,
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