Reference of 147118-40-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.147118-40-9, name is Rosuvastatin methyl ester, molecular formula is C23H30FN3O6S, molecular weight is 495.56, as common compound, the synthetic route is as follows.
The fraction obtained in preparative HPLC is evaporated under reduced pressure (ca 200 mbar) to 50 ml and coled in freezer (ca -20°C) for 3 days. The suspension is filtered. The obtained crystals are dried under vacuum at 40 °C for 5 hours yielding 0,57 g of dry product, containing ca 11 percent of enantiomer; The fraction obtained in preparative HPLC is evaporated under reduced pressure (ca 200 mbar) to 50 ml and coled in freezer (ca -20°C) for 3 days. The suspension is filtered. The obtained crystals are dried under vacuum at 40 °C for 5 hours yielding 0,57 g of dry product, containing ca 11 percent of enantiomer; The filtrate of previous step is evaporated under reduced pressure and dried under vacuum at 40 °C for 5 hours yielding 0,43 g of dry product, containing less than 0,1percent of 3S, 5R enantiomer. The product is enantimerically pure MER having 99,9 percent enantiomeric purity, , as shown on Fig.4
The chemical industry reduces the impact on the environment during synthesis 147118-40-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; LEK Pharmaceuticals d.d.; EP2022784; (2009); A1;,
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