Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C10H4Cl2N2S
Compound sub 1 (30 g, 118 mmol) andThe compound sub 2 (29 g, 118 mmol) was dispersed in tetrahydrofuran (300 mL), and a 2M potassium carbonate aqueous solution (aq. K2CO3) (176 mL, 352 mmol) was added. Tetraquistriphenylphosphinopalladium Pd (PPh3) 4] (1.4 g, 1 mol%) was added thereto, followed by stirring under reflux for 12 hours. The temperature was lowered to room temperature and the resulting solid was filtered. percolationThe resulting solid was recrystallized from tetrahydrofuran and ethyl acetate, filtered and then dried to give compound H2 (35 g, yield 71%)
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Reference:
Patent; LG Chem, Ltd.; Jeong Min-u; Lee Dong-hun; Moon Jeong-uk; Park Tae-yun; Lee Jeong-ha; Cho Seong-mi; Chae Mi-yeong; (43 pag.)KR2018/10166; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
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