Adding a certain compound to certain chemical reactions, such as: 17573-78-3, 4,5,6-Trifluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 17573-78-3, blongs to pyrimidines compound. Formula: C4HF3N2
Example 1 To a mixture obtained by adding 110.0 g of 4,5,6-trifluoropyrimidine, 114.6 g of potassium carbonate and 16.6 g of triethylamine to 220.0 g of toluene, 60.4 g of 2-butyn-1-ol is added dropwise at 25 to 30C over one hour, followed by stirring at 30C. Then, 220.0 g of water is added dropwise into the reaction mixture, followed by stirring. Then, 85.4 g of 3, 3-dimethylpyrrolidine is added dropwise and, after the mixture is stirred at 30C, the reaction mixture is allowed to stand. After separating into the organic layer and the aqueous layer, the aqueous layer is removed and the organic layer is washed once with 220.0 g of 5% hydrochloric acid and then washed once with 220.0 g of water. The organic layer is concentrated to obtain 4-(2-butynyloxy)-5-fluoro-6-(3,3-dimethylpyrrolidin-1-yl)py rimidine (hereinafter referred to as the present compound (1)).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17573-78-3, its application will become more common.
Reference:
Patent; Sumitomo Chemical Company, Limited; EP2011795; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia