1820-81-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1820-81-1, name is 5-Chlorouracil, molecular formula is C4H3ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture of pyrimidine (1mmol) and ammonium sulfate (0.10mmol) in HMDS (1.5 ml) was refluxed until clear solution was obtained (3h). Then alkyl bromide (2mmol, 0.22ml), KI (0.5mmol, 83mg) and acetonitrile (2.5ml) were added. Reaction mixture was heated at 90C for 5h. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with dichloromethane and evaporated to dryness. The residue was purified by flash chromatography eluting with MeOH/dichloromethane (1/10).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1820-81-1, 5-Chlorouracil, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mansouri, Az-Eddine El; Zahouily, Mohamed; Lazrek, Hassan B.; Synthetic Communications; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia