Electric Literature of 18592-13-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18592-13-7, name is 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.
A mixture of 18 (0.252 g; 0.5 mmol), 6-chloromethyluracil (0.088g ; 0.55 mmol), K2CO3 (0.076 g; 0.55 mmol) and NaI (0.082 g; 0.55 mmol) in acetonitrile (5 ml) was heated at [85C] under argon atmosphere for 4 hours. The mixture was purified by flash chromatography eluting with a gradient of 5-10 % [MEOH/CH2C12] to give Example 11 as a solid. Yield: 63 [%] [‘H] NMR [(CDC13)] : 1.2-1. 4 (m, 4H); 1.6 (s, 6H); 1.4-1. 8 (m, 4H); 2.34 (s, 6H); 2.4-2. 7 (m, 10H); 2.85-2. 95 (m, 2H); 3.3 (s, 2H); 4-4.2 (m, br, 1H); 4.6-4. 8 (m, br, 1H); 5.53 (s, 1H); 6.72 (s, 1H) ; 6.93 (s, 1H); 7.04 (s, 2H); 8.05-8. 2 (m, 2H). MS-ESI: 629 [M+H] [+]
At the same time, in my other blogs, there are other synthetic methods of this type of compound,18592-13-7, 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/18480; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia