Adding a certain compound to certain chemical reactions, such as: 36082-45-8, 2-Amino-5-bromo-4-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H6BrN3O, blongs to pyrimidines compound. Formula: C5H6BrN3O
Intermediate U: 4-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine A mixture of 2-amino-5-bromo-4-methoxypyrimidine [36082-45-8] (11.1 mmol), bis(pinacolato)diboron (12.2 mmol), PdCl2(dppf).CH2Cl2 adduct (0.555 mmol) and potassium acetate (33.3 mmol) in dioxane (60 mL) was stirred at 115 C. under argon for 20 h, allowed to cool to rt, diluted with toluene (60 mL), sonicated, and filtered through celite. The celite cake was rinsed with hot toluene (2*). The filtrate was concentrated to afford the title compound (30% purity) which was used without purification. ESI-MS: tR=0.22 min; [M+H]+ 170 (boronic acid) (LC-MS 1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,36082-45-8, 2-Amino-5-bromo-4-methoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; Cotesta, Simona; Furet, Pascal; Guagnano, Vito; Holzer, Philipp; Kallen, Joerg; Mah, Robert; Masuya, Keiichi; Schlapbach, Achim; Stutz, Stefan; Vaupel, Andrea; US2013/317024; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia