Electric Literature of 4763-35-3 ,Some common heterocyclic compound, 4763-35-3, molecular formula is C5H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Preparation of 89 10240] Step 3. Into a 100 mE round bottom flask equippedwith a magnetic stir bar was placed 2-Amino-4-hydroxy-S-methoxy-pyrimidine (500 mg, 3.54 mmol), anhydrous DMF (30 mE), AA-13 (1.27 g, 5.31 mmol), DI3U (2.12 mE, 14.17 mmol), and HOP (1.96 g, 4.43 mmol). The reaction mixture was allowed to stir at room temperature for 30 minutes then at 50 c. for 16 hours. The solvent was removed under reduced pressure and the residue was partitioned between brine and ethyl acetate. The organic layers were combined, dried (magnesium sulfate), the solids were removed via filtration, andthe solvents of the filtrate were removed under reduced pressure. The crude was purified via reverse phase liquid chromatography (RP Vydac Denali c18-10 jim, 250 g, Scm. Mobilephase 0.25% NH4HcO3 solution in water, methanol), the bestfractions were pooled, the solvents were removed underreduced pressure to afford 89.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4763-35-3, its application will become more common.
Reference:
Patent; McGowan, David; Raboisson, Pierr Jeane-Marie Bernar; Embrechts, Werner; Jonckers, Tim Hugo Maria; Last, Stefaan Julien; Pieters, Serge Maria Aloysius; Vlach, Jaromir; US2014/45849; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia