Electric Literature of 2915-16-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. A new synthetic method of this compound is introduced below.
Under a nitrogen atmosphere, 50g (187mmol) the compound 2-chloro-4,6-diphenyl pyrimidine was dissolved in 1LTHF added thereto 37g (155mmol) (3- bromophenyl) borate, and 2.1g (1.8mmol) tetrakis (triphenylphosphine) palladium, and the mixture was stirred. Subsequently, thereto added 64g (467mmol) of potassium carbonate saturated aqueous solution, and the resulting mixture was heated at reflux for 80 12 hours. When the reaction was completed, water was added to the reaction solution, and the mixture was extracted with dichloromethane ((the DCM), followed by removal of water and dried over anhydrous MgSO4 filtered and concentrated under reduced pressure. The residue obtained was separated via flash column and chromatography to obtain 66g (92%) compound I-17.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2915-16-4, 2-Chloro-4,6-diphenylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Samsung SDI Co., Ltd.; Jin, Chengxuan; Jin, Yongquan; Liu, Dongwan; Jin, Lunhuan; Liu, Yinshan; Zheng, Chengxian; (85 pag.)CN105566200; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia