Some scientific research about 2-Chloropyrimidine-5-carbonitrile

With the rapid development of chemical substances, we look forward to future research findings about 1753-50-0.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1753-50-0, name is 2-Chloropyrimidine-5-carbonitrile, molecular formula is C5H2ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Chloropyrimidine-5-carbonitrile

To a stirred solution of compound CD (0.55 g, 3.96 mmol) in EtOH (10 mL), 2-chloropyrimidine-5-carbonitrile (AF, 0.9 g, 3.96 mmol) and DIPEA (1.53 g, 11.9 mmol) were added at 80C and the reaction mixture was stirred at 90C for 12 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using 20% EtOAc/hexane to afford compound CE (0.6 g, 46 %) as a yellow oil. LC-MS: m/z 331.10 [M+H]+. 1H NMR (400 MHz, DMSO- 6) _ 9.17 (s, 1H), 8.72- 8.69 (m, 2H), 7.66 – 7.62 (m, 2H), 7.52 (d, J = 8.0 Hz, 2H), 7.28 – 7.20 (m, 4H), 1.36 -1.28 (m, 4H).

With the rapid development of chemical substances, we look forward to future research findings about 1753-50-0.

Reference:
Patent; VPS-3, INC.; YATES, Christopher, M.; (397 pag.)WO2018/165520; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia