Some scientific research about 2022-78-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2022-78-8, its application will become more common.

Application of 2022-78-8 ,Some common heterocyclic compound, 2022-78-8, molecular formula is C4H3FN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 4 1-(2-Hydroxyethyl)-5-fluoropyrimid-2-one 5-Fluoropyrimid-2-one (0.008 mol) was dissolved in a solution of potassium hydroxide (0.008 mol) in absolute ethanol (100 ml) at 80 C. and ethylene bromohydrin (0.008 mol) added gradually with stirring. The alkylation was incomplete when the pH had become neutral. The reaction was further monitored by chromatography and equivalent amounts of potassium hydroxide and ethylene bromohydrin added until all the pyrimidine had been alkylated. The reaction mixture was then filtered and the filtrate evaporated to dryness before the residue was triturated with ether and extracted with warm acetone. Evaporation of the acetone solution left the title compound in 50% yield, m.p. 134-136 C. after recrystallisation from ethanol; Found: C, 45.83; H, 4.42; Calc. for C6 H7 FN2 O2: C, 45.58; H, 4.46.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2022-78-8, its application will become more common.

Reference:
Patent; Nyegaard & Co. A/S; US4395406; (1983); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia