Electric Literature of 26032-72-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 26032-72-4, name is 2,4-Dichloro-6-phenylpyrimidine. A new synthetic method of this compound is introduced below.
The respective dichloropyrimidine derivative 9 (75 mg) and 1.5 equivalents of 1-methylpiperazine are dissolved in DMF (2.00 mL). The reaction mixture is heated to 40 C and stirred for 18 hours. Subsequently, the solvent is removed under reduced pressure and the crude product is purified via column chromatography (SiO2, ethyl acetate / methanol = 3:1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26032-72-4, its application will become more common.
Reference:
Article; Hammer, Sebastian G.; Gobleder, Susanne; Naporra, Franziska; Wittmann, Hans-Joachim; Elz, Sigurd; Heinrich, Markus R.; Strasser, Andrea; Bioorganic and Medicinal Chemistry Letters; vol. 26; 2; (2016); p. 292 – 300;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia