Electric Literature of 90213-66-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90213-66-4, name is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 2 (1 g, 5.318 mmol) and powdered KOH (446 mg, 7.978 mmol) was dissolved in 4 mL anhydrous DMSO. After 1 h at RT, the reaction mixture was quenched with water and the aqueous layer was extracted with EtOAc (2x).The organics were combined, dried (MgSO4), filtered and the volatiles were removed in vacuo. The residue was purified by flash chromatography (Sitheta2, hexanes/EtOAc, 2:1 ) to provide the desired product (892 mg, 83%) as a colourless solid. 1H NMR (CZ6-DMSO) delta 7.76 (1 H, d, J = 3.6 Hz), 6.70 (1 H, d, J= 3.6 Hz), 3.82 (3H, s).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 90213-66-4, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine.
Reference:
Patent; VERNALIS (R & D) LTD.; WO2009/37467; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia