With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.25746-87-6, name is 4-Dimethoxymethylpyrimidine, molecular formula is C7H10N2O2, molecular weight is 154.17, as common compound, the synthetic route is as follows.HPLC of Formula: C7H10N2O2
To the solution of 3.90 g of 4-(dimethoxymethyl)pyrimidine (25.3 mmol) in 100 mLAcOll 4.15 g sodium acetate (50.6 mmol) and 8.08 g bromine (50.6 mmol) were addedand the mixture was stirred at 40C for 7 h. Reaction mixture was concentrated underreduced pressure, DCM was added to the residue, and it was washed with saturated aq.NaHCO3. The organic phase was dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified via flash chromatography using heptane and EtOAc as eluents to give 5-bromo-4-(dimethoxymethyl)pyrimidine, 1HNMR(400 MHz, DMSO-d6): 9.18 (s, 111), 9.06 (s, 111), 5.51 (s, IH), 3.40 (s, 611).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,25746-87-6, 4-Dimethoxymethylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia