Reference of 26032-72-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 26032-72-4 as follows.
General procedure: The respective dichloropyrimidine derivative 9 (between 60 mg and 120 mg) and 1.5 equivalents of the respective amine are dissolved in DMF (2.00 mL). The reaction mixture is heated to 40 C and stirred for 18 hours. Subsequently, the solvent is removed under reduced pressure and the crude product is purified via column chromatography (SiO2, dichloromethane / ethyl acetate = 20:1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26032-72-4, its application will become more common.
Reference:
Article; Hammer, Sebastian G.; Gobleder, Susanne; Naporra, Franziska; Wittmann, Hans-Joachim; Elz, Sigurd; Heinrich, Markus R.; Strasser, Andrea; Bioorganic and Medicinal Chemistry Letters; vol. 26; 2; (2016); p. 292 – 300;,
Pyrimidine | C4H4N2 – PubChem,
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