Application of 289042-12-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, molecular weight is 577.71, as common compound, the synthetic route is as follows.
A mixture of BEM (5.0 g) and acetonitrile (35 ml) was stirred under an inert atmosphere at 40 C. 0.02M hydrochloric acid (9.5 ml) was added over 30 minutes to the resultant solution, maintaining the temperature at 35 C. to 42 C. The mixture was stirred at 40 C. for 3 hours then cooled to 25 C. 1.0M sodium hydroxide solution (9.5 ml) was added with stirring at 25 C. and the mixture was stirred for an additional one hour at 25 C. Sodium chloride (4.7 g) was added and the mixture was cooled to -5 C. over one hour. Sufficient of a solution of 1M hydrochloric acid (9.5 ml) and sodium chloride (2.4 g) was added at -5 C. to achieve a pH of 3.4 to 4.0 and the mixture stirred at this temperature for 5 minutes. The mixture was allowed to settle for 10 minutes at -5 C. to give two layers. The lower layer was separated and discarded. Acetonitrile (65 ml) at -5 C. was added to the remaining solution and the mixture was filtered through a filter agent. 40% methylamine solution in water (1.1 ml) was added at -5 C. and the mixture was warmed to 30 C. over 40 minutes and maintained at this temperature for 90 minutes. The mixture was then cooled to 0 C. over 40 minutes and maintained at this temperature for 90 minutes. The resultant solid was collected by filtration and washed with acetonitrile (2¡Á12 ml). The solid, which is the methylamine salt of the compound of formula IV (R1=MeNH3+), was dried under vacuum at 35 C. (3.87 g). 8% w/w aqueous sodium hydroxide (5.44 ml) was added to a stirred mixture of the methylamine salt (6.0 g) in degassed water (30 ml) at 20 C. and the mixture was stirred for one hour. The mixture was filtered and concentrated under reduced pressure at 40 C. until 24 ml of distillate collected. Water (24 ml) was added and the mixture again concentrated under reduced pressure at 40 C. until 24 ml of distillate collected. Water (30 ml) was added and a solution of calcium chloride dihydrate (1.03 g) in water (6 ml) was added dropwise at 20 C. The mixture was stirred for 45 minutes and the resultant solid filtered. The solid was washed with water (36 ml) and dried under vacuum at 40 C. to give the calcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid.
Statistics shows that 289042-12-2 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate.
Reference:
Patent; Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William; US2008/207903; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia