Reference of 29509-92-0 ,Some common heterocyclic compound, 29509-92-0, molecular formula is C11H9ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 4-chloro-6-methyl-2-phenylpyrimidine (1 g, 4.89 mmol) and piperidine-4-carboxamide (0.627 g, 4.89 mmol) and trimethylamine (1.02 mL, 7.34 mmol) in anhydrous DMF (25 mL) was heated to reflux for 4 hours, upon completion, the reaction mixture was cooled to room temperature, and then was concentrated to dry, the residue was stirred in a mixed solution of EtOAc (10 mL) and water (20 mL) for about 30 min. and then the solid product was collected by filtration to obtain 1.4 g compound, then it was re-crystallized from EtOH/H20, after dry obtained 900 mg of the title compound as a white solid in 62% yield. MS (MH+) 297.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29509-92-0, 4-Chloro-6-methyl-2-phenylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FIRMENICH INCORPORATED; SERVANT, Guy; CHEN, Qing; FOTSING, Joseph, R.; ZHANG, Lan; PATRON, Andres; WILLIAMS, Mark; BRADY, Thomas; PRIEST, Chad; DARMOHUSODO, Vincent; SIMONE, Kenneth; WONG, Melissa, S.; (204 pag.)WO2020/33669; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia