Reference of 1032452-86-0 ,Some common heterocyclic compound, 1032452-86-0, molecular formula is C13H10ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In 80 mL of sec-butanol, 2.44 g (10.04 mmol) of compound 2, 2.60 g (15.06 mmol) of p-toluenesulfonic acid and 2.48 g (10.04 mmol) of 4-bromo-5-nitro 2-methoxyaniline were added. The mixture was reacted at 90 C for 20 hours, detected by TLC, and the reaction was completed.It cooled to room temperature, concentrated to give a black solid, which was successively washed with acetonitrile and methyl tert-butyl ether to give 2.58 g (5.68 mmol) of Compound 3 The crude yield of 56.56 %
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1032452-86-0, its application will become more common.
Reference:
Patent; Beijing Xuanyi Pharmaceutical Technology Co., Ltd.; Jilin Huikang Pharmaceutical Co., Ltd.; Song Yuntao; A .J.buliqi; (90 pag.)CN104761544; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia